Don Luis was kidnapped by Spanish explorers in 1561 from what is now coastal Virginia. He was Native, possibly Kiskiack or Paspahegh both of which were member tribes of the Powhatan confederacy. He was taken to Spain, Cuba, and Mexico before accompanying Juan Baptista de Segura back to Virginia to establish a Jesuit mission. Upon his return he promptly abandoned the Jesuit missionaries and returned to his people. The priests were not well provisioned and it was a bad year for food so they almost immediately became completely dependent on the local Native peoples. In February 1571, Don Luis returned with other natives and stole all their remaining supplies, killing the priests and the rest of the party, sparing a young servant boy. A Spanish supply ship came in the spring where some natives explained what had happened and then the servant boy returned and explained more of the story in 1572. Don Luis was never turned over to the Spanish. This failed attempt was the end of the Spanish attempts to colonize the area, perhaps in part due to Don Luis actions.