Also known as the Battle of a Thousand Slain, Miami leader Mihšihkinaahkwa, Shawnee leader Weyapiersenwah, and Lenape leader Buckongahelas led Northwest Indian Confederacy forces to a decisive win against the US Army during the Northwest Indian War. Still described as "the most decisive defeat in the history of the American military," the Native forces includes Miamis, Lenape, and many Potawatomis against ~1000 US military men. Only 24 American's escaped and it led to the first ever congressional inquiry into the federal branch. This defeat followed the earlier defeats by Harmar's forces. Another prelude to this battle was the capture of Mihšihkinaahkwa's daughter by the US Army in August of that year at the battle of Kenapacomaqua. After three hours of fighting, St. Clair and the remaining officers attempted to fight out an escape, intentionally abandoning their women and children. The casualty rate was the highest percentage ever suffered by a United States Army unit and included St. Clair's second in command, Richard Butler. Of the 52 officers engaged, 39 were killed and 7 wounded; around 88% of all officers had become casualties.

The Rebellion of Túpac Amaru II was an uprising by kuraka-led Aymara, Quechua, and mestizo rebels aimed at overthrowing Spanish colonial rule in Peru, from 1780 to 1783. The causes of the rebellion included opposition to the Bourbon Reforms, an economic downturn in colonial Peru, and a grassroots revival of Inca cultural identity led by Túpac Amaru II, an indigenous kuraka and the leader of the rebellion. While Amaru II was captured and executed by the Spanish in 1781, the rebellion continued for at least another year under other rebel leaders. Among Túpac Amaru II's proclamations were the demands of the freedom of the indigenous population and the abolition of slavery.